根據上海市醫學會《關於推薦2023年度上海醫學科技獎的通知》（滬醫會(2023)48號）的有關規定，現將我單位提名2023年度上海醫學科技獎的項目進行公示。
項目名稱：靶向腫瘤微環境的分子影像診療一體化新策略及其基礎研究
完成人（完成單位）：黃鋼（熊猫体育官网）🆙，田啟威（熊猫体育官网），楊浩（熊猫体育官网），靳明明（熊猫体育官网），楊仕平（上海師範大學）🦬，鄒華華（熊猫体育官网）🧑🏼🏭🧖🏼♂️，安璐（上海師範大學），薛峰峰（熊猫体育官网）
公示時間🚔：2023年10月18日-2023年10月24日
公示期間，任何單位或者個人對公示項目持有異議的，以書面形式向熊猫体育提出🙍🏿，並提供必要的證明文件👷🏿♀️。為便於核實、查證，確保實事求是、公正地處理異議🥯，提出異議的單位或者個人應當表明真實身份🍺，並提供聯系方式🧑🏫。個人提出異議的，應當在書面異議材料上簽署真實姓名；以單位名義提出異議的🥓，應當加蓋本單位公章。凡匿名異議和超出期限的異議一般不予受理。
聯系人⌚️：張霞，電話：021-65882010，郵箱：zhangx_10@sumhs.edu.cn。
熊猫体育
熊猫体育官网
2023年10月18日
附公示內容
項目名稱🫎🫰🏽：靶向腫瘤微環境的分子影像診療一體化新策略及其基礎研究
完成人（含排序）：黃鋼，田啟威，楊浩，靳明明，楊仕平👃🏽，鄒華華，安璐，薛峰峰
完成單位（含排序）：熊猫体育官网🐧，上海師範大學
提名單位👫🏻：熊猫体育官网
項目目的：本項目旨在闡明腫瘤微環境及相關成分對於腫瘤惡性進展的新機製🖨，並以這些微環境調控模式及相關化學反應為觸發開關，設計開發特異性的診療一體化的分子影像新探針或試劑，同時篩選靶向微環境調控的安全☄️、穩定的新藥物及中藥單體，期望為腫瘤的臨床精準診療提供新的理論依據和實踐指導👨🏼。
代表性論文情況🎋：
序號 | 論文 | 第一作者 | 通訊作者 | 發表年份 | 在線發表時間 | 影響因子 |
1. | Lu An, Xiaodong Wang, Xichuan Rui, Jiaomin Lin, Hong Yang, Qiwei Tian, Cheng Tao, Shiping Yang, The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics. Angewandte Chemie International Edition 2018, 57, 15782-15786. | An, Lu; Wang, Xiaodong | Tian, Qiwei; Yang, Shiping | NOV 26 2018 | OCT 11 2018 | 16.6 |
2. | Lu An, Chengbin Wang, Qiwei Tian, Cheng Tao, Fengfeng Xue, Shiping Yang, Xuesu Zhou, Xiaoyuan Chen, Gang Huang, NIR-II laser-mediated photo-Fenton-like reaction via plasmonic Cu9S8 for immunotherapy enhancement. Nano Today 2022, 43, 101397. | An, Lu | Tian, Qiwei; Yang, Shiping; Chen, Xiaoyuan; Huang, Gang | APR 2022 | JAN 18 2022 | 17.4 |
3. | Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang, Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2. Theranostics 2021, 11, 2860-2875. | Wang, Dongliang | Yang, Hao; Huang, Gang | 2021 | JAN 01 2021 | 12.4 |
4. | Hao Yang, Rongxuan Zhu, Xiaoping Zhao, Liu Liu, Zhaoli Zhou, Li Zhao, Beibei Liang, Wenjing Ma, Jian Zhao, Jianjun Liu, Gang Huang, Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma. Oncogene 2019, 38, 4915-4931. | Yang, Hao; Zhu, Rongxuan | Liu, Jianjun; Huang, Gang | JUN 20 2019 | MAR 11 2019 | 8 |
5. | Hao Yang, Xiaoping Zhao, Jianjun Liu, Mingming Jin, Xiyu Liu, Jun Yan, Xufeng Yao, Xinyi Mao, Nan Li, Beibei Liang, Wei Xie, Kunchi Zhang, Jian Zhao, Liu Liu, Gang Huang, TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity. Oncogene 2023, 42, 35-48. | Yang, Hao | Zhao, Jian; Liu, Liu; Huang, Gang | JAN 3 2023 | NOV 10 2022 | 8 |
6. | Lu An, Mei Cao, Xue Zhang, Jiaomin Lin, Qiwei Tian, Shiping Yang, pH and Glutathione Synergistically Triggered Release and Self-Assembly of Au Nanospheres for Tumor Theranostics. ACS Applied Materials & Interfaces 2020, 12, 8050-8061. | An, Lu | Tian, Qiwei; Yang, Shiping | FEB 19 2020 | JAN 29 2020 | 9.5 |
7. | Mingming Jin, Chunzi Shi, Tian Li, Yue Wu, Cheng Hu, Gang Huang, Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system. Biomedicine & pharmacotherapy🕚，2020, 129, 110282. | Jin, Mingming; Shi, Chunzi; Li, Tian | Hu, Cheng; Huang, Gang | SEP 2020 | JUN 9 2020 | 7.5 |
8. | Mingming Jin, Yue Wu, Yuqing Lou, Xiyu Liu, Yitian Dai, Wenxiao Yang, Congbiao Liu, Gang Huang, Corosolic acid reduces A549 and PC9 cell proliferation, invasion, and chemoresistance in NSCLC via inducing mitochondrial and liposomal oxidative stress. Biomedicine & Pharmacotherapy 2021, 144, 112313. | Jin, Mingming; Wu, Yue; Lou, Yuqing; Liu, Xiyu; Dai, Yitian | Yang, Wenxiao; Liu, Congbiao; Huang, Gang | DEC 2021 | OCT 19 2021 | 7.5 |
9. | Yue Wu, Dongliang Wang, Yuqing Lou, Xiyu Liu, Pinzheng Huang, Mingming Jin, Gang Huang, Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis–mediated glutathione oxidation-reduction system. Biomedicine & Pharmacotherapy 2022, 150, 112927. | Wu, Yue; Wang, Dongliang; Lou, Yuqing; Liu, Xiyu | Jin, Mingming; Huang, Gang | JUN 2022 | APR 7 2022 | 7.5 |
10. | Fengfeng Xue, Shuntao Zhu, Qiwei Tian, Ruomeng Qin, Zerong Wang, Gang Huang, Shiping Yang, Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors. Journal of Colloid and Interface Science 2023, 629, 554-562. | Xue, Fengfeng | Tian, Qiwei; Huang, Gang; Yang, Shiping | JAN 2023 | SEP 5 2022 | 9.9 |